https://www.sankarghoshlab.org/home daily 1.0 2023-04-26 https://images.squarespace-cdn.com/content/v1/5c114b113c3a53eaebd7fdfb/1544638457128-LQNC74L6N0C1XAQGU9K7/IMG_0210.JPG Home https://images.squarespace-cdn.com/content/v1/5c114b113c3a53eaebd7fdfb/1549664792928-QZB08VDLQHRBX48TH0EO/3.jpg Home - Felipe Leao POST-DOCTORAL RESEARCH SCIENTIST fbl2113@cumc.columbia.edu I am currently a postdoctoral research scientist at the Ghosh Lab. I am currently studying the transcriptional regulation of a recently described TLR-inducible gene, trying to identify some of the genomic regions and molecular mechanisms responsible for its induced expression in macrophages. My favorite thing to do in NYC is going to bars that have a good selection of beers, food, and great live music. Lots of options, so I think it is impossible to get bored here. https://images.squarespace-cdn.com/content/v1/5c114b113c3a53eaebd7fdfb/1550017386147-KZX49YUA1UUDEXYSIA0A/4.jpg Home - Jingyao Zhao Post-Doctoral Research Scientist jz3095@cumc.columbia.edu I recently joined the Ghosh lab after completing my PhD at the Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Science. In my previous lab, I mainly focused on hematopoietic stem cells and T cells. In the Ghosh lab, my main interest is about the immunotherapy to cancer. I hope to improve cancer therapy through this research. When I am out of lab, I like running, cooking Chinese food, and hiking. https://images.squarespace-cdn.com/content/v1/5c114b113c3a53eaebd7fdfb/1602680052789-HF15GIH9OAN8P753L9GH/silhouette.jpg Home - Christine Ghobrial POST-DOCTORAL RESEARCH SCIENTIST cg3249@cumc.columbia.edu I am postdoctoral research scientist with an interest in studying cancer immunology. My current project centers around identifying molecules that target the NF-kB pathway for the purpose of cancer immunotherapy. Within the city, I enjoy spending time with friends and family. I also enjoy exploring to discover what’s in my “backyard”. https://images.squarespace-cdn.com/content/v1/5c114b113c3a53eaebd7fdfb/1550017569498-DLR4ZHL0MDK1IWECU8GJ/5.jpg Home - Alyssa Shearer PhD Candidate ams2481@cumc.columbia.edu I am a graduate student in the Nutritional and Metabolic Biology department at CUMC, with interests in genetics, nutritional biochemistry, and the immune system. I am currently studying how long non-coding RNAs regulate gene expression and inflammation within the intestinal immune system. This project will help to elucidate genetic susceptibility to inflammatory bowel diseases, such as Celiac Disease, whose genetic underpinnings are largely unknown. My favorite things to do in NYC are going on runs in Central Park, eating lots of good vegetarian food, and visiting the many art museums. https://images.squarespace-cdn.com/content/v1/5c114b113c3a53eaebd7fdfb/1602679979918-0HR9XZBLSWBIFFTDCZAG/RuxiaoTian.jpg Home - Ruxiao Tian PhD Candidate rt2750@cumc.columbia.edu I am a graduate student in the Department of Microbiology & Immunology at Columbia University. I am interested in genetics, molecular biology, and immunology. I am currently studying how certain long non-coding RNAs regulate inflammation and how the dysfunctional regulation of these lncRNAs contribute to autoimmune diseases like celiac disease and systemic lupus erythematosus. Outside of the lab, I play the cello. My favorite things to do in NYC are going to new restaurants, taking pictures of NYC, and going on long walks at riverside park. https://images.squarespace-cdn.com/content/v1/5c114b113c3a53eaebd7fdfb/1602680052789-HF15GIH9OAN8P753L9GH/silhouette.jpg Home - Andry Dominguez Executive Assistant Department of Microbiology and Immunology ad3270@cumc.columbia.edu I am the Assistant to the Chairman of Microbiology and Immunology who is also the head of the Ghosh Lab. https://images.squarespace-cdn.com/content/v1/5c114b113c3a53eaebd7fdfb/1557427684902-PMUSBP9NJLBJ4WY14ZG7/Ghosh-headshot-.jpg Home - Sankar GHOSH, PH.D. Chairman and Silverstein and Hutt Family Professor of Microbiology & Immunology sg2715@cumc.columbia.edu Dr. Ghosh received his Ph.D. in Molecular Biology from the Albert Einstein College of Medicine in 1988. He carried out his postdoctoral research as an Irvington Institute postdoctoral fellow with Dr. David Baltimore at the Whitehead Institute of MIT in Cambridge, MA. It was there that Dr. Ghosh began his seminal work in understanding the regulation of Nuclear Factor-kappa B (NF-kappa B / NF-kB), a transcription factor that plays a critical role in regulating the expression of a large number of genes involved in the mammalian immune system. Dr. Ghosh’s research led to the first cloning of NF-kB and IkB proteins, and their characterization, including the demonstration of the role of IkB phosphorylation in the activation of NF-kB. Dr. Ghosh began his independent research career at Yale University School of Medicine in 1991, where he was a Professor in the Departments of Immunobiology and Molecular Biophysics & Biochemistry, and an Investigator of the Howard Hughes Medical Institute. At Yale his laboratory made numerous original findings that helped establish the mechanism of transcriptional regulation of NF-kB proteins, identification and characterization of signaling intermediates in innate and adaptive immune system, and identification and characterization of a subset of Toll-like receptors. In 2008 he was recruited to Columbia University to be the chairman of the Department of Microbiology and Immunology. A biochemist, immunologist and microbiologist, Dr. Ghosh continues to be best known for his work on NF-kB. Because NF-kB plays an important role in regulating the expression of a number of genes involved in inflammation and the immune responses, his research has implications for the treatment of arthritis, colitis, dermatitis, asthma, and other inflammatory diseases, as well as diseases such as cancer and muscular dystrophy. However his research interests have expanded over the years and encompasses the study of long non-coding RNAs and microRNAs in the inflammatory process. His recent work has also illuminated novel mechanisms and pathways by which the NF-kB pathway influences immune responses to cancer. Curriculum Vitae (CV) https://images.squarespace-cdn.com/content/v1/5c114b113c3a53eaebd7fdfb/1602679551642-RD0HNQLQTT0K2LHU0YRA/Vincent%2BGuichard.jpg Home - Vincent Guichard POST-DOCTORAL RESEARCH SCIENTIST vag2141@cumc.columbia.edu After completing my Ph.D. in Paris, where I worked on naïve T cell and the pathways essential for their differentiation, I joined the Ghosh lab as postdoctoral research scientist. Here, I study the activation of innate lymphoid cells. I am currently focused on the NF-kB pathway in the ILC2s. In New York City I enjoy walking in the park with my dog, hanging out with my friends and finding new bars or restaurants to try. https://images.squarespace-cdn.com/content/v1/5c114b113c3a53eaebd7fdfb/1550017491919-3MH0OVYT2NHGZ7HIPD56/SuneetaKrishnareddy.jpg Home - Suneeta Krishnareddy Assistant Professor of Medicine sk3222@cumc.columbia.edu I am a gastroenterologist at Columbia University, and have been working in the lab since 2014. I am studying the role of toll like receptors on commensalism and disease susceptibility. We are trying to determine the role of the innate immune system in determining commensal colonization and how this then leads to differences in susceptibility to infectious and inflammatory GI conditions. My favorite thing to do in the city is go for bike rides with my family along the west side highway, and end up either at Dinosaur Barbecue or Ample Hills Creamery. https://images.squarespace-cdn.com/content/v1/5c114b113c3a53eaebd7fdfb/1550017825567-VR6X0AX5NEJ6CAS1V3OU/silhouette.jpg Home - Crystal Bussey Lab Manager cb2720@cumc.columbia.edu I have been a member of the Ghosh lab for many years and have had the opportunity to work with many wonderful students, postdocs and faculty over that time. As I often interface with various research labs, collaborators, administrative offices, regulatory agencies and vendors, I see first-hand the intricacies of life in a research community. It’s exciting to know that in some way you may contribute to the next great discovery. My favorite things to do in New York are visiting Times Square like I’ve never seen it before, eating my way from the west side to the east side, and watching the beautiful sunsets over the Hudson. https://images.squarespace-cdn.com/content/v1/5c114b113c3a53eaebd7fdfb/1549664163703-RXOGZ7N9CNKJ8PKHZKQJ/DSC03218.JPG Home https://images.squarespace-cdn.com/content/v1/5c114b113c3a53eaebd7fdfb/1544639328000-I4AVH7DYEAW4EIDTV3VK/2013-02-15_10-41-46_291.jpg Home https://images.squarespace-cdn.com/content/v1/5c114b113c3a53eaebd7fdfb/1544640499253-TCM4YY70S0WQ40TLDA3F/DSC05084.jpg Home Lab dinner party at ? https://images.squarespace-cdn.com/content/v1/5c114b113c3a53eaebd7fdfb/1550250615405-9EYTTY56RU0BCXQKVJ12/DSC06312.JPG Home That lab bowling expedition. https://images.squarespace-cdn.com/content/v1/5c114b113c3a53eaebd7fdfb/1550250507825-WHP6KT4XFXVURMZNNOJE/DSC04747.JPG Home Party at Sankar’s place. https://images.squarespace-cdn.com/content/v1/5c114b113c3a53eaebd7fdfb/1550250818574-6G1GGKNI4D5F26KZVB24/IMG_1851.JPG Home We escaped! The lab breaks out of an escape room. https://images.squarespace-cdn.com/content/v1/5c114b113c3a53eaebd7fdfb/1550250732469-PFJO61A3M0SW5V3IRUKA/DSC01523.JPG Home Celebrating Suja’s doctoral defense! https://images.squarespace-cdn.com/content/v1/5c114b113c3a53eaebd7fdfb/1550250679668-RD8Y4E7CTVM35EEVPABH/DSC06324.JPG Home Lab rooftop party! https://images.squarespace-cdn.com/content/v1/5c114b113c3a53eaebd7fdfb/1544639819409-BKRRMDNY7VD6AFWOP5A8/20180810_130941.jpg Home https://images.squarespace-cdn.com/content/v1/5c114b113c3a53eaebd7fdfb/1549670013370-B8JH2RFBYNBM2TMG1ME2/publications.jpg Home https://images.squarespace-cdn.com/content/v1/5c114b113c3a53eaebd7fdfb/1549670350689-AY7HNXE4ZQQNG99D9SSG/dinnerparty.jpg Home https://images.squarespace-cdn.com/content/v1/5c114b113c3a53eaebd7fdfb/1549672634939-MZ76R7YK4YQ9P8WV4NX1/group-photo-final.jpg Home https://images.squarespace-cdn.com/content/v1/5c114b113c3a53eaebd7fdfb/1556833614385-NE0DT868R6CLTTP1ZMJZ/NFKB_mechanism_of_action.png Home https://www.sankarghoshlab.org/visit-us daily 0.75 2019-06-16 https://www.sankarghoshlab.org/sankar-ghosh-honors-and-awards daily 0.75 2023-04-26 https://www.sankarghoshlab.org/sankar-ghosh-headshot-2023 daily 0.75 2023-05-08 https://images.squarespace-cdn.com/content/v1/5c114b113c3a53eaebd7fdfb/21b21ffb-a957-4467-93a8-e3dbb9527524/ghosh-headshot-CC0.jpeg Public Domain Headshot of Sankar Ghosh in 2023 - Make it stand out Photograph of Sankar Ghosh, Chair of Microbiology & Immunology, Columbia University in 2023